Applying Advanced Protein Engineering Technologies to Biotherapeutic Development
Abstract:
By applying its CodeEvolver® directed evolution technology, Codexis has been improving enzymes for specific functions in challenging environments for well over a decade, using high-throughput gene synthesis, biochemical screening and advanced data analytics. Recently we have demonstrated that this technology can impact biologic drug candidate discovery and optimization. By applying the same core technology and optimization philosophies successfully demonstrated in engineering biocatalysts for the synthesis of small-molecule active pharmaceutical ingredients (APIs), we are now fundamentally changing the properties of biologics to generate novel and potentially more effective drug candidates.