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Step into the Future of RNAi
Codexis delivers scalable, sustainable enzymatic synthesis of therapeutic RNA.
Next-Generation RNA Manufacturing, Built to Scale
Evolve beyond traditional RNA synthesis with top-tier enzyme engineering enabling scalable, sustainable, high-quality, and efficient manufacturing. Our ECO Synthesis® Manufacturing Platform delivers efficient solutions that slot seamlessly into existing processes. This platform delivers scalable RNA manufacturing through greener, modular workflows — offering ligation-based and sequential synthesis options.
We deliver scalable RNA solutions that reduce process complexity, improve manufacture of RNA therapeutics, and accelerate the path from innovation to impact — with sustainability built in, not bolted on.
One Platform, Multiple Modalities
Whether you are developing siRNA therapeutics, guide RNAs for gene editing, or antisense oligonucleotides, the ECO Synthesis Manufacturing Platform provides flexible manufacturing approaches designed to address the unique challenges of each modality.
siRNA
As RNAi programs progress toward larger patient populations and commercial-scale supply, developers need manufacturing strategies that can support growing demands for scale, quality, and consistency. ECO Synthesis provides a flexible enzymatic manufacturing platform designed to address these evolving requirements.
Potential benefits include:
- Scale for larger indications
- Quality and reproducibility
- Sequential and ligation-based approaches
- PS stereochemistry capabilities
sgRNA
As sgRNAs become longer, more modified, and more structurally complex, full-length chemical synthesis becomes increasingly inefficient. ECO Synthesis addresses this challenge by assembling shorter, high-quality RNA fragments into full-length guides using engineered ligases optimized for manufacturing, helping developers overcome key manufacturing constraints associated with complex guide RNA programs.
Potential benefits include:
- Access to long and complex guide designs
- Increased manufacturing success rates
- More predictable supply
- Lower risk for clinical and commercial programs
Antisense Oligonucleotides (ASOs)
As antisense oligonucleotides become longer, more highly modified, and more structurally complex, manufacturing challenges increase. ECO Synthesis uses engineered ligases to assemble optimized fragments into full-length ASOs, helping simplify manufacturing while supporting quality, scalability, and manufacturability from development through commercialization.
Potential benefits include:
- Greater scalability from clinical to commercial supply
- Improved overall product yield
- Reduced impurity burden and simplified purification workflows
- Lower manufacturing risk
- Potential access to longer and more highly modified oligonucleotide designs
Why RNA Innovators Choose Codexis
Built for What’s Next
Our platform was intentionally engineered to make RNA therapies sustainable at scale.
Solutions for Tough Challenges
We create innovative solutions for RNA manufacturing
Faster, Cleaner, Scalable Results
Enzyme-powered processes deliver higher yield, fewer impurities, and repeatable success for therapeutic RNA manufacturing.
Decades of Enzyme Engineering
20+ years of enzyme engineering and redefining what’s possible in RNAi.
Explore RNA Solutions That Scale
From pilot scale to commercial manufacture, our enzyme-enabled services help you reach the clinic faster — and scale with confidence.
RNA Ligation Services
Fragment design and bespoke ligase variant screening enable robust ligation workflows, built for scale-up and manufacturability.
RNA Sequential Synthesis Services
Our ECO Synthesis® Manufacturing Platform delivers scalable RNA manufacturing through greener, modular workflows including sequential synthesis options.
RNA Manufacturing FAQs
Have questions about our RNA manufacturing services?
We’ve answered the most common to the right. Need deeper insight or a custom quote? Our technical team is ready to help, contact us below.
A proprietary RNA manufacturing platform that integrates enzymatic sequential synthesis and ligation workflows — enabling higher yield, greater purity, and sustainable scalability.
Yes. Our ECO Synthesis® Innovation Lab enables enzymatic process design and optimization — supporting GLP scale synthesis and preparing workflows for tech transfer to commercial partners.
Yes — our library of engineered ligases are designed for tough sequences and scale-up readiness. We also provide enzyme evolution services to create a ligase tailored to your asset.
Primarily siRNA, with intake for gRNA and ASO projects.
A 20+ year legacy, industry-defining enzyme engineering platforms, and the science to solve what traditional methods can’t.
Explore RNA Manufacturing Innovation
Dive into case studies, publications, and data sheets demonstrating the science behind our RNA manufacturing solutions.
Unlocking the Future of RNA Manufacturing: A Guide to Enzymatic Synthesis
Computational Fragment Design for Efficient Ligation-based siRNA Synthesis
Comparative Analysis of Diastereomeric Distribution in siRNA Synthesis: SPOS vs Enzymatic Synthesis
Oligonucleotide CMC for Sustainable and Scalable Enzymatic siRNA Manufacturing
Process Development for Enzymatic Synthesis of RNAi Therapeutics
Improving siRNA Production Efficiency
Let’s Build Your RNA Future
Our experts are ready to support your project. Let’s unlock the full potential of enzymatic RNA manufacturing — together.