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Webinar: Biocatalytic Cascades | Challenges and Opportunities

Biocatalytic cascades involving two or more enzymes hold the promise to facilitate complex, multi-step chemical transformation in efficient and sustainable ways. In vivo cascades are assembled by metabolic engineering and have a well-established track-record from the bench to large-scale fermentation. In contrast, in vitro cascades have recently breached proof-of-concept in the test tube by successfully demonstrating their scalability for industrial production of high-value compounds, such as the anti-retroviral drug islatravir, and the low-calorie rare sugar tagatose.

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