Discovery and Development at Codexis

Discovery and Development

Collaborative development

Since the start, Codexis has partnered with established and emerging companies.  We continue to offer many research and development partnership options to develop and deliver quality engineered solutions and provide a path to successful commercialization. This is carried out through a highly engaged and collaborative approach. Take the step to explore new possibilities and begin a conversation today.

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Discovery pathways


We screen existing enzyme libraries to find suitable starting enzymes for your application. Our enzyme libraries contain cumulative knowledge gained from proprietary machine-learning software, as well as decades of expertise and guidance from our scientists. Commercially relevant enzymes can sometimes be identified at this stage.


A short project usually consisting of two rounds of evolution, a proof-of-concept program applies the CodeEvolver® technology platform to optimize an enzyme’s performance. This offers a relatively inexpensive risk calibration and quantification of the enzyme’s potential for improvement, as well as, a useable enzyme for a partner’s process development.


Working in close partnership with R&D and business stakeholders to define target performance characteristics, we apply our technology to improve and tailor enzyme attributes. An intermediate enzyme is delivered to enable verification of ongoing improvement and application-relevant feedback to the evolution program. A final, optimized enzyme in quantities sufficient to validate meeting a partner’s commercial objectives is delivered, prior to investing in scale-up and commercialization.

Benefits of optimizing enzymes

Faster process development

Faster process development

Engineered enzymes have similar biochemistry at any scale, minimizing the need for process changes when scaling up.



Optimized enzymes do not require elevated pressures or temperatures and can be adapted for longer reaction sequences.

Cleaner and more environmentally friendly

Cleaner and more environmentally friendly

Replacing traditional chemistry processes with Codexis enzymes typically reduces general waste and particularly hazardous waste.

There are many steps to a healthier future.

Join us on our journey.