Applications at Codexis


Solving real-world challenges

Engineered enzymes can drive improvements such as higher yields, reduced energy usage and waste generation, improved efficiency in manufacturing, greater sensitivity in genomic and diagnostic applications, and potentially more efficacious therapeutics. The enzymes we produce solve for real-world challenges associated with pharmaceutical manufacturing, and life sciences. As biotherapeutic candidates – they have the potential to treat challenging diseases.

Target applications

Pharmaceutical Manufacturing

Highly customized biocatalysts can transform API manufacturing processes by eliminating steps, increasing yield, and reducing solvent usage and waste.

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RNA Manufacturing

When manufacturing mRNA for therapeutic applications, the process ideally delivers high yields and minimizes unwanted byproducts, while being economically sound. Engineered enzymes can overcome the particular obstacles faced in the production of quality mRNA at commercial scale.

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Oral Enzyme Therapy

Highly stable and active recombinant oral enzyme therapies can potentially benefit patients. We engineer enzymes that are highly stable to the harsh conditions of the gastrointestinal tract, including the low pH of the stomach and the protease-rich upper intestines.

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NGS Library Prep

Many NGS workflows are critically dependent on library preparation. Engineered enzymes play a key role in effective library preparation to lay the groundwork for high quality sequencing results under increasingly diverse and demanding conditions.

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Nucleic Acid Detection

Nucleic acid detection methods are valuable diagnostic tools which rely on enzymes to amplify a range of starting samples. Engineered enzymes that have been tailored for real-world laboratory and physiological conditions achieve faster time to results under a wider range of challenging conditions.

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Gene Therapy

Engineered proteins may offer improved targeting, expression, and potency when administered as gene therapies. Our partnered product candidates with Takeda are for rare lysosomal storage disorders such as Fabry Disease, Pompe Disease, and a blood factor disorder.

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