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Our CodeEvolver Enzyme Engineering Platform

Codexis’ proprietary platform for rapid, real-world enzyme optimization at scale.

Purpose-Built for Performance and Scale

CodeEvolver® Technology Platform is Codexis’ proprietary platform for enzyme engineering. Continuously evolved over 20+ years, it integrates machine learning, bioinformatics, and lab workflows to design enzymes with optimized function, performance, and manufacturability.

Unlike generic AI tools, CodeEvolver was built for real-world impact — enabling scalable, sustainable solutions across pharma, RNA therapeutics, and diagnostics.

One Platform. Fully Integrated Process.

Design to Data, in One Loop

Our process connects computational design and experimental validation — enabling fast, informed engineering cycles.

Built on Proprietary Machine Learning Tools

Our machine learning tools are trained on 20+ years of relevant Codexis experimental data, not just publicly available data sets.

Rapid Engineering Cycles

Enzyme variants can be designed, built, and tested in as little as one week.

Market-Agnostic by Design

Used in pharma, RNA, and diagnostic applications — the platform adapts to your use case in any field.

Not Just Software

CodeEvolver integrates seamlessly with our in-house lab workflows to deliver an enzyme built to your exact specifications. It’s more than predictive — it performs for you.

Why CodeEvolver Delivers Results

Outcomes that matter, from development to deployment.

Accelerate Development Timelines

Enzyme cycles in as little as one week.

Design for Manufacturability

Built with scale-up and robustness in mind.

Apply Across Modalities

From API chemistry to RNA to diagnostics.

Partnered with Industry Leaders

Proven value with Merck, GlaxoSmithKline, and Novartis.

Unlock Therapeutic Possibilities at Scale

We make complex science scalable with enzyme-powered solutions that deliver real-world therapeutic impact.

See our solutions

RNA manufacturing

Evolve beyond traditional chemistry with a modern and efficient approach that slots seamlessly into your existing process. Our enzyme-enabled RNA manufacturing platform delivers superior quality, higher yield, better manufacturability and faster results — through a greener solution. A future you can believe in, sooner than you thought possible.

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Pharma biocatalysis

Transform complex, resource-intensive processes into precise, efficient and sustainable breakthroughs. Our proprietary enzymes — powered by CodeEvolver® Technology Platform — enable greener processes, faster pathways and world-class quality from grams to tonnes. Unlock new possibilities with pharma biocatalysisand elevate your process with sustainable chemistry designed to optimize API synthesis.

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Molecular biology and diagnostic applications

Codexis redefines enzyme performance for molecular biology and diagnostic applications. Our CodeEvolver® platform enables tailored enzyme solutions with improved fidelity, enhanced selectivity, and increased activity, delivering faster reaction times to power your applications. As your trusted partner for enzyme evolution, we deliver precision-optimized solutions that power performance.

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