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A kinase-cGAS cascade to synthesize a therapeutic STING activator

Published in Nature Portfolio and co-authored by Codexis scientists Margie Borra-Garske, Oscar Alvizo and Da Duan, “A kinase-cGAS cascade to synthesize a therapeutic STING activator”, describes the discovery and construction of an enzymatic cascade to MK-1454, a highly potent stimulator of interferon genes (STING) activator under study as an immuno-oncology therapeutic.

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