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Overcoming Therapeutic Deficiencies in Lysosomal Storage Disease Treatments Using Directed Evolution

Poster abstract:

Using our proprietary CodeEvolver® protein engineering platform, which entails high-throughput protein expression, high-throughput activity and cell-based assays, next-generation sequencing, and bioinformatics, we have identified α-galactosidase A (GLA) and α-glucosidase (GAA) variants with superior properties for addressing Fabry and Pompe diseases, respectively.

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