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Products  >  Screening Kits and Biocatalysts

Our Enzymes, Your Scientists – This Could Lead to Something Great

codexis-screening-kits

Codexis’ Codex® Screening Kits let you rapidly determine the feasibility of using our engineered enzymes in your own facilities. Each kit contains a carefully selected set of enzymes that have been engineered for enhanced activity, selectivity, substrate range, solvent and temperature stability.

Conveniently packaged in individual vials for easy use and with enough enzyme for several screens and hit verification, our kits include protocols and co-reagents for use and are easy to use. Follow-on quantities of all kit enzymes are stocked in 50–100g quantities to enable rapid delivery.

Biocatalyst Platforms

Codexis also provides a full range of quality biocatalyst platforms

Ketoreductases use nicotinamide cofactors as electron donors to reduce carbonyls to alcohols.

Transaminases are versatile enzymes that use isopropylamine as an amine donor to convert ketones to chiral amines in one step.

Imine Reductases have been engineered to exhibit totally novel intermolecular reductive amination activity on unactivated substrates.

Nitrilases are enzymes capable of hydrolyzing nitriles to carboxylic acids at neutral pH and ambient temperature.

Baeyer-Villiger Monooxygenases have been developed for asymmetric sulfoxidation using ambient oxygen as the oxidant.

Monoamine Oxidases use ambient oxygen as an oxidant, providing a safe and mild way to generate imines from amines.

Halohydrin Dehalogenases were developed for the production of ethyl (R)-(−)-4-cyano-3-hydroxybutyrate, the first chiral building block in the synthesis of the atorvastatin side chain.

Ene Reductases are capable of reducing carbon-carbon double bonds using a nicotinamide cofactor as the electron donor.

Acylases are derived from penicillin G acylase and have improved activity and stability over the native enzyme.

MicroCyps® enzymes provide medicinal chemists with unique tools to produce metabolites and generate potentially new leads with higher productivity over mammalian CYPs.

 

This is just a short list of the enzyme classes we’re experienced with. To find out about others, please contact us.

Codexis screening kits are the ideal starting point for further evolution using our powerful CodeEvolver® protein engineering platform. Kits are competitively priced and sold under simple but comprehensive “shrink-wrap” IP terms.

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