Advancing Sustainability through Innovation in Oligonucleotide Manufacturing

Overview

The rapid growth of therapeutic oligonucleotides is placing unprecedented pressure on manufacturing infrastructure—and on sustainability expectations. Traditional chemistries rely heavily on hazardous reagents and organic solvents, posing environmental, safety, and scalability challenges.

This talk, featured at TIDES USA 2026, highlights how enzymatic innovation is enabling a more sustainable path forward for RNA manufacturing.

Abstract

The growing demand for therapeutic oligonucleotides requires new, efficient, scalable, and sustainable manufacturing solutions. This presentation showcases Codexis’ ECO Synthesis® Manufacturing Platform—an enzymatic process for producing high‑quality siRNA under fully aqueous conditions. By eliminating highly reactive chemicals and dramatically reducing acetonitrile use, ECO Synthesis enables a more sustainable approach to RNA manufacturing without sacrificing performance or scale.

Key Takeaways

• Sustainability challenges facing traditional oligonucleotide manufacturing
• How fully aqueous, enzymatic processes reduce environmental impact
• The role of solvent reduction in scalable siRNA production
• Aligning manufacturing innovation with ESG and long‑term capacity needs

Who Should Attend

Manufacturing leaders, sustainability teams, and developers seeking scalable RNA production solutions with a reduced environmental footprint.