Home / Technical Content / Smarter siRNA Ligation: Fragment Design Delivers Precision and Efficiency
Smarter siRNA Ligation: Fragment Design Delivers Precision and Efficiency
With FragLink™, a Computational Fragment Design Approach
This application note reviews how ligation-based methods combined with FragLink, a computational fragment design approach, can deliver for siRNA manufacturing. The ECO Synthesis® Manufacturing Platform supports both fully enzymatic and hybrid ligation workflows, while integrated computational fragment design, enhances ligation performance and process predictability. This combination supports:
- Higher yield in full-length product (FLP)
- Superior impurity profile from ligase
- De-risk ligase selection and fragment design
- Greater than 90% ligation efficiency guaranteed for a fragment disconnect strategy of your choice
- Faster turnaround time with reduce the need for lengthy screenings, saving weeks
See how in this application note today.
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