Codex® HiCap RNA Polymerase at Codexis

Codex® HiCap RNA Polymerase

Improve mRNA capping efficiency with Codex® HiCap RNA Polymerase

Achieve exceptional IVT results with Codex® HiCap RNA Polymerase, a co-transcriptional capping RNA polymerase that has been uniquely engineered to produce synthetic mRNA at high yield and low immunogenicity.

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Benefits of Codex® HiCap RNA Polymerase

More translatable mRNA with greater capping efficiency

Specifically designed to improve capping efficiency over current methods while reducing cap analog requirements, the Codex® HiCap RNA Polymerase increases yields of fully capped mRNA without compromising the total RNA yield.

Reduced immunogenicity from double-stranded RNA

Reduce the negative immune responses from your vaccine and therapeutic candidates with Codex® HiCap RNA Polymerase, which produces significantly less double-stranded RNA (dsRNA) compared to wild-type T7 RNA polymerase.

Flexible uracil analog incorporation

Codex® HiCap RNA Polymerase incorporates commonly used uracil analogs to replace canonical uracil (which can also elicit an unintended immune response) during IVT and is able to incorporate a range of commercial uracil analogs.

OEM enzyme supply

You can tailor Codex® HiCap RNA Polymerase purchase quantities, concentrations and fill-volumes to meet your demands and integrate seamlessly into your IVT production process. To learn more, please contact us, or visit the Scale-up and Supply page.

Life science enzymes portfolio

Three life science enzymes are currently available for commercial use: a thermostable reverse transcriptase for one-step RT-qPCR assays, a high-fidelity DNA polymerase for next-generation sequencing, and an RNA polymerase with significantly improved co-transcriptional capping. 

Codex® HiTemp Reverse Transcriptase

Reverse transcription at 70 °C

Codex® HiTemp Reverse Transcriptase is a highly sensitive enzyme engineered for thermostability at temperatures as high as 70 °C. In addition, it is stable at ambient temperature and automation-friendly, making it ideal for custom one-step RT-qPCR assays. 

Robust and thermostable

Codex® HiFi Hot Start DNA Polymerase

High-fidelity results for NGS

Codex® HiFi Hot Start DNA Polymerase delivers high-fidelity results when applications demand exceptionally accurate DNA sequences. Our enzyme produces 2.5 times more accurate results than the current market-leading, high-fidelity DNA polymerase.

Improve sequence accuracy

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