Biocatalysts at Codexis

Transaminases perform the asymmetric conversion of ketones to chiral amines using isopropylamine as an amine donor.

Ketoreductases perform the asymmetric reduction of carbonyls to alcohols using nicotinamide cofactors as electron donors.

Ene Reductases perform the symmetric reduction of carbon-carbon double bonds in carbonyl conjugated alkene substrates using nicotinamide cofactors as electron donors.

Nitrilases are enzymes capable of hydrolyzing nitriles to carboxylic acids at neutral pH and ambient temperature.

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Imine Reductases perform the asymmetric synthesis of secondary and tertiary chiral amines from imines, or ketones and amines.

Monoamine Oxidases convert amines to imines (asymmetric or resolution) using ambient oxygen as the oxidant.

Our Esterases are capable of amide synthesis using corresponding ester and amine substrates, as well as ester hydrolysis.

Acylases are capable of ester formation/transesterification or ester hydrolysis.

Codexis’ engineered Baeyer-Villiger Monooxygenases perform the asymmetric oxidation of sulfide to sulfoxide using ambient oxygen as the oxidant, and with nicotinamide as a cofactor.

Halohydrin Dehalogenases perform nucleophilic displacement of halogen in a halohydrin.