Biocatalysts at Codexis


Feasibility screening with confidence in rapid scalability

Codexis enzyme screening kits provide an easy and rapid way to determine the feasibility of using our engineered enzymes. Each kit contains carefully selected enzymes engineered for enhanced activity, selectivity, substrate range, solvent and stability. For instance, our most popular screening kit, KRED, contains 24 ketoreductases that are cumulated from more than 70 screening projects. Immediate follow-on quantities of 50g-100g of all kit enzymes are available for development work, with larger quantities available for custom order to suit your scale-up plans.

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Our portfolio of biocatalysts

Codexis offers a full range of quality enzymes to help you meet your sustainability goals and lower your cost-in-use.

Transaminases perform the asymmetric conversion of ketones to chiral amines using isopropylamine as an amine donor.

Ketoreductases perform the asymmetric reduction of carbonyls to alcohols using nicotinamide cofactors as electron donors.

Ene Reductases perform the symmetric reduction of carbon-carbon double bonds in carbonyl conjugated alkene substrates using nicotinamide cofactors as electron donors.

Nitrilases are enzymes capable of hydrolyzing nitriles to carboxylic acids at neutral pH and ambient temperature.

MicroCyp® P450 enzymes provide medicinal chemists and development scientists with unique tools to generate new molecules and metabolites. The Elite MicroCyp® enzymes are improved over our Standard MicroCyp® enzymes and have shown to be more active, have increased solvent tolerance and show greater substrate promiscuity. This makes them a valuable option where novel compounds or larger quantities of products are required.

Imine Reductases perform the asymmetric synthesis of secondary and tertiary chiral amines from imines, or ketones and amines.

Monoamine Oxidases convert amines to imines (asymmetric or resolution) using ambient oxygen as the oxidant.

Our Esterases are capable of amide synthesis using corresponding ester and amine substrates, as well as ester hydrolysis.

Acylases are capable of ester formation/transesterification or ester hydrolysis.

Codexis’ engineered Baeyer-Villiger Monooxygenases perform the asymmetric oxidation of sulfide to sulfoxide using ambient oxygen as the oxidant, and with nicotinamide as a cofactor.

Halohydrin Dehalogenases perform nucleophilic displacement of halogen in a halohydrin.

Accordion Notes

This does not list all our available enzyme classes. If you do not see what you need, please contact us for further information and discussions.

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