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Scaling RNA therapeutics sustainably using the ECO Synthesis Manufacturing Platform
Featured at TIDES Europe 2025
Scaling RNA Therapeutics Sustainably with the ECO Synthesis Manufacturing Platform
Rapidly growing therapeutic oligonucleotide demand for large indications require innovative manufacturing solutions. Answering the call for a more scalable and sustainable process, Codexis introduced the ECO Synthesis® Manufacturing Platform — a fully aqueous, enzymatic, high yielding production approach for safe, quality, and efficacious siRNA. In this presentation, we characterize a 10 g synthesis of siRNA using the ECO Synthesis platform. Through the ECO Innovation lab, Codexis can now deliver up to 100 grams of GLP grade RNA to support tox studies. We will showcase how ECO Synthesis can transition from research to manufacturing scale and cGMP production while highlighting its potential to exceed productivity of traditional SPOS.
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