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TIDES USA 2025: Oligonucleotide CMC for Sustainable and Scalable Enzymatic siRNA Manufacturing
Oligonucleotide CMC for Sustainable and Scalable Enzymatic siRNA Manufacturing
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The demand for RNA therapeutics is rapidly growing—bringing with it the challenge of scaling up manufacturing to meet that need. This presentation will explore the impurity profiles, product yields, and reproducibility of various enzymatic processes, and compare these approaches to traditional phosphoramidite chemistry-based oligonucleotide synthesis.
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