RNA Leaders Europe Congress 2026

Rapidly growing therapeutic oligonucleotide demand for indications with large patient populations require innovative manufacturing solutions. Answering the call for a more scalable and sustainable process, Codexis introduced the ECO Synthesis® Manufacturing Platform — a fully aqueous, enzymatic high yielding production approach for safe, quality, and efficacious siRNA. In this presentation, we will demonstrate the scalability of ECO Synthesis while illustrating the ability to transition from research to manufacturing scale and cGMP production, highlighting its potential to exceed productivity of traditional SPOS.

Robust in-process control (IPC) testing is critical to achieving consistent product quality and purity in oligonucleotide manufacturing. Conventional solid-phase oligonucleotide synthesis (SPOS) presents IPC testing limitations due to the closed reaction environment and resin-bound intermediates. This platform, ECO Synthesis, enables early detection of process performance and/or deviations, and the opportunity for closed loop adjustment of reaction parameters in the future, resulting in high standards of API product quality, ensuring patient safety.