Fully optimized and formulated for next-generation sequencing workflows, the Codex® HiFi Hot Start DNA Polymerase allows developers of NGS library preparation kits or diagnostic molecular assays to create kits that will give customers more confidence in their data, reducing the number of total reads required, even for low sample inputs, or at decreased depths of coverage.
With an approximately 400-fold increase in fidelity relative to Taq and greater than 2.5-fold improvement relative to the current market-leading, high-fidelity DNA polymerase, DNA libraries will be amplified with fewer errors, providing higher confidence in the data even at decreased depths over coverage.
Enhanced uniformity of coverage
Decreased GC bias increases library complexity and the number of unique reads. This means that fewer total reads are required to achieve a target mean depth of coverage, in turn providing higher confidence in the data with decreased coverage depth.
Including a proprietary aptamer to provide hot start specificity, libraries are amplified with high yields, critical for low sample inputs and workflows such as hybrid capture.
OEM enzyme supply
Looking for another engineered life science enzyme?
Sequencing & detection
Codexis’s novel enzymes are engineered to improve accuracy, speed, and overall robustness of your sequencing or diagnostic workflows such as NGS library preparation or RT-qPCR.
DNA & RNA synthesis
Our next-generation enzymes improve yield, speed and cost of oligonucleotide synthesis. We have worked on single and double-stranded ligases, polymerases, nucleases, and others.
We enable novel biosensors for human and environmental monitoring. Through the directed evolution of biomolecules, we can unlock the full potential of your device and revolutionize quality of life.