Codexis and Merck Amend and Extend Supply Agreement for Enzyme Used in Manufacture of Sitagliptin
Highly customized biocatalysts can transform active pharmaceutical ingredients (API) manufacturing processes by eliminating steps, increasing yield, and reducing solvent usage and waste. Furthermore, carefully designed multi-step, biocatalytic cascades can be assembled in single reactors to accomplish difficult chemical reactions under mild reaction conditions, which expands the capability, and the efficiency, of sustainable biocatalytic processes at large scale.Catalysis or biocatalysis?
For many of our global partners, optimized biocatalytic processes enabled by our engineered enzymes have reduced improved capital utilization, yield and quality attributes while achieving desired yield, and several pharmaceutical industry partners have taken the partnership even further and licensed our technology to develop and expand their in-house use of custom enzymes API production.
Out of 70+ programs and millions of variants analyzed, we offer our best-performing enzymes to you, available in grams to multi-ton scale. The Codex® Ketoreductase Screening Kit has been widely used in active pharmaceutical ingredients synthesis as well as other industrial research areas.
Discover more about our screening kit products.
This article published in the journal ACS Catalysis describes how we engineered an amine transaminase to improve upon the synthesis of sacubitril, a key component in Entresto® for the treatment of chronic heart failure.Read article