Science, powered by enzymes

Enzymes naturally evolved across diverse and sometimes hostile environments. Their unique characteristics have powered many life science tools. For example, the thermostability of Taq Polymerase enabled DNA amplification through PCR, instituting a new era of genomics, and the activity of glucose oxidase was instrumental to the glucose meter marking the genesis of enzymatic biosensors. However, these natural enzymes have limitations and through enzyme engineering, evolved enzymes are unlocking next-generation tools.

Evolving for the future

The next generation of life science tools will require the next generation of enzymes. Scientists are no longer limited to scouring the world for enzymes that evolved over eons for naturally occurring conditions. Now, enzymes can be rapidly tailored for real world laboratory and physiological conditions to unlock the life science tools of tomorrow.

We are improving life science tools with a focus on genomics and nucleic acid synthesis.

Genomic tools

Infectious disease testing at a global scale has highlighted the need for faster, more sensitive tools, such as RT-qPCR and isothermal amplification. More complex tools, such as DNA/RNA sequencing, epigenetic analysis, and more, require similar improvements. Our proprietary portfolio of next-generation enzymes work efficiently under challenging sample conditions so that genomic tools can perform beyond the natural limitations of wild-type enzymes.

Partnerships

Alphazyme LLC
Roche

Nucleic acid synthesis

We are building a complete portfolio of next-generation enzymes for the synthesis and modification of DNA and RNA. Our portfolio includes single and double-stranded ligases, template-dependent and independent polymerases, nucleases, and others.

Partnership

Molecular Assemblies

Life science enzymes

Three life science enzymes are available for commercial use: a thermostable reverse transcriptase for one-step RT-qPCR assays, a high-fidelity DNA polymerase for next-generation sequencing, and an RNA polymerase with significantly improved co-transcriptional capping.

Codex® HiTemp Reverse Transcriptase

Reverse transcription at 70 °C

Codex® HiTemp Reverse Transcriptase is a highly sensitive enzyme engineered for thermostability at temperatures as high as 70 °C. In addition, it is stable at ambient temperature and automation-friendly, making it ideal for custom one-step RT-qPCR assays. 

Robust and thermostable

Codex® HiCap RNA Polymerase

Improve mRNA capping efficiency

Produce capped synthetic mRNA at high yield and low immunogenicity with Codex® HiCap RNA Polymerase. Greater capping efficiency and the production of less double-stranded RNA byproduct deliver exceptional IVT results

Efficient RNA capping

Codex® HiFi Hot Start DNA Polymerase

High-fidelity results for NGS

With enhanced uniformity of coverage and the ability to amplify difficult genomic regions, Codex® HiFi Hot Start DNA Polymerase is suited for NGS library amplification in human WGS and targeted resequencing workflows.
Improve sequence accuracy

Latest News

Codexis and Molecular Assemblies Announce Execution of Commercial License and Enzyme Supply Agreement for Optimized TdT Enzyme for Enzymatic DNA Synthesis

Codexis and seqWell Announce Strategic Investment and Partnership Initiation

Scientific highlights

AGBT 2021 Presentation: Codex® HiFi Hot Start DNA Polymerase

This video walks through the four key characteristics we focused on when engineering the Codex® HiFi Hot Start DNA Polymerase, and how it was specifically tailored to improve the amplification steps in an NGS workflow. The presentation also includes an overview of our technology, and the novel enzymes we create for life science tools.

Watch Video

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