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SynBioBeta 2022

January 25 – 27, 2022

Location: Oakland, CA

Breaking the Barrier to Long, High Purity Synthetic DNA

The use of synthetic biology is becoming established in a diverse range of high value, high growth markets. From food and agriculture to therapeutics, diagnostics, and vaccines; tools such as gene editing, DNA sequencing and gene synthesis are being used to build value-added products with advanced functionality (e.g., cell bioreactors, etc.) and desired end products (e.g., drugs, chemicals, etc.). The barrier to widespread implementation is the forty-year-old Phosphoramidite DNA synthesis chemistry that is limited to producing only short oligonucleotides.

Molecular Assemblies is developing a proprietary enzymatic chemistry and high-throughput platform that will break the barrier to producing long, high purity synthetic DNA. A key component of the chemistry is the development of engineered polymerases which are capable of efficient template-independent DNA synthesis. In collaboration with Molecular Assemblies, Codexis is leveraging its CodeEvolver® directed evolution platform to improve the efficiency and speed of nucleotide incorporation at elevated temperatures. Taken together, these advances will revolutionize the field of synthetic biology.

Speakers:

Matt Miller, Principal Scientist, Molecular & Cellular Engineering, Codexis

Bill Efcavitch, Co-founder and Chief Scientific Officer, Molecular Assemblies

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