A pharmaceutical intermediate Close
IntermediateA material produced during the synthesis of an API. An intermediate undergoes molecular change or purification before it becomes the API. Each reaction step may create one or more intermediates. is a chemical compound formed in a stage between the raw materials and the final active pharmaceutical ingredient (API)CloseActive Pharmaceutical Ingredient (API)The pharmaceutically active substance (molecule) in a drug.. It is a stepping stone to the final product. With more and more new APIs being chiral,CloseChiralA chiral molecule is asymmetric, it cannot be superimposed on its mirror image. Many chemicals important to life are chiral. The US FDA requires that the two mirror image forms (‘enantiomers’) of a chiral compound be treated as different products that must be tested separately. Consequently, there has been extensive research into developing methods for making one or the other of the enantiomers – in other words, making the molecule chirally pure. the demand for stereochemically pure intermediates is increasing.
Using proprietary biocatalysts,CloseBiocatalyst or Biological CatalystA catalyst derived from a living organism. Enzymes and fermentation strains are common biocatalysts. Biocatalysts significantly speed chemical reactions. Codexis manufactures chirally pure intermediates and APIs. Codexis technology can significantly reduce the cost and capital expenditure required to provide the desired intermediate with improved purity and reduced environmental waste.