Case Study:
Biocatalyst Panels Case Study
Download Codex™ Biocatalyst Panel Product Information Sheets
- Codex™ Biocatalyst Panels Overview
- Codex™ Ketoreductase (KRED) Panels
- Codex™ Acylase Panels
- Codex™ Ene Reductase (ERED) Panels
- Codex™ Transaminase (TA) Panels
- Codex™ Halohydrin dehalogenase (HHDH) Panels
Codexis has created panels of genetically diverse biocatalysts for use in pharmaceutical process research and development. Codexis is now making this diverse collection of proprietary enzymes available to the pharmaceutical community. These enzymes have been developed using Codexis proprietary biocatalysis platform technology and optimized for use in pharmaceutical process R&D. The variant enzymes are provided in convenient 96-well format to efficiently determine if a biocatalytic solution is available for a chemically challenging process step.
Codexis has created panels of genetically diverse biocatalysts for use in pharmaceutical process research and development.
Codex™ Biocatalyst Panels: The next generation in biocatalysis technologies
Codexis now offers sets of its proprietary biocatalysts that are “pre-tuned” to perform under chemical process conditions suitable for pharmaceutical manufacturing, to accept a wide range of substrates, and importantly, to provide sequence-function information that can guide the design of a collection of “fine-tuned” biocatalyst candidates specific for the substrate of interest. The result of this new technology dramatically reduces the development time required to generate a suitable biocatalyst to perform a particular reaction. Now, in a matter of months, process research chemists can move from initial screening of a Codex™ Biocatalyst Panel to generating the first kilo quantities of desired material. If required to meet process performance objectives, Codexis can further optimize the biocatalyst using its proprietary directed evolution technology.(For example, refer to Fox, et al., Nature Biotechnology, 25, 338-344).
Codex™ Biocatalyst Panels are currently offered or in development for five enzyme classes and can be used for developing biocatalysts to produce the following types of products:
Enzyme Class |
Typical Products |
| Ketoreductases (Codex™ KRED) | Chiral alcohols |
| Acylases (Codex™ ACY) | Chiral amines or alcohols via resolution of amides or esters |
| Ene reductases (Codex™ ERED) | α and/or β chiral ketones, esters and nitriles |
| Transaminases (Codex™ TA) | Chiral amines |
| Halohydrin dehalogenases (Codex™ HHDH) | Chiral halohydrins, cyanohydrins, amino alcohols, epoxides, diols |