Over millions of years, microorganisms have evolved to produce a host of enzymes that rapidly convert readily available materials necessary for their survival. Microbial processes that take place in natural environments, however, do not translate effectively to commercial manufacturing environments. The Codexis technology platform includes highly sophisticated gene shuffling and systems biology techniques. This platform enables Codexis scientists to engineer microbial genomes and enzyme pathways to create organisms capable of large-scale production of fuels and other chemical products.